APOE4 Update: Memory Restored + 3 More Findings You Need To Know

Memory reversed in mice, social factors override genetics, vascular damage starts at 40, and immune cells won't calm down

Author

Dr. Kevin Tran
July 19, 2025

New data from the Alzheimer's Association APOE Conference (March 2025):

Finding 1: Deleting APOE4 from vascular mural cells (pericytes) restored spatial memory in mice. Zero changes to neurons needed.

Finding 2: Among 1,000+ Brazilian brains studied, APOE4 carriers with high education + social support maintained cognition despite equal plaque burden.

Finding 3: VEGF-R2 drops 45% by age 12-14 months in APOE4 mice. Vascular density follows. This equals your 40s-50s.

Finding 4: APOE4 microglia show 3x higher CD68 expression. Even after complete depletion/repopulation, hyperreactivity persists.

I break down what each finding means for your daily protocol in this video.

→ Watch the full analysis: