Turning Off the ApoE4 Gene To Prevent Alzheimer’s ?!

Insights on myelin, CRISPR gene silencing, lipid metabolism, and prevention.

Author

Dr. Kevin Tran
June 20, 2025

Hi friends,

In this episode, I break down two groundbreaking Alzheimer’s prevention discoveries—directly from the Alzheimer’s Association International Conference on APOE and Lipid Biology (March 2025).

These insights reveal how APOE4 disrupts brain metabolism decades before symptoms begin—and what researchers are doing to stop it.

You’ll discover:

  • How lipid droplet buildup in oligodendrocytes could be one of the earliest signs of brain dysfunction in ApoE4 carriers

  • A groundbreaking CRISPR interference technique that silences APOE4 in neurons—without editing your DNA

  • Why targeting GSK3-beta and Wnt signaling could help restore healthy fat metabolism and protect myelin

  • Why these findings matter now—for prevention, resilience, and smarter protocols